Empowering the role of small and medium-sized enterprises in the age of digital economy and the development of digital entrepreneurship in them is important because these companies, especially if they are Knowledge-based, are known as important sources of income, employment and ultimately the driving force influencing economic development. Accordingly, the purpose of this study is to provide a model for the development of digital entrepreneurship in small and medium-sized Knowledge-based companies in order to empower them. Therefore, in the first step of the research, the study background, semi-structured interviews and qualitative method of content analysis were used to identify the factors influencing the development of digital entrepreneurship and the creation of a basic framework. The results of the research show seven effective factors of business model, product innovation strategy, resource configuration, environmental factors, digital entrepreneurship ecosystem, individual factors and organizational factors in the development of digital entrepreneurship in three structural, contextual and content dimensions, which are environmental factors and entrepreneurial ecosystem. Digital have the greatest impact on the development of digital entrepreneurship in small and medium-sized Knowledge-based companies.